HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester | HCID 69652265 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic Acid | HCID 22052488 | — |
Reaction Steps
To a solution of 400 mg 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester in 5 ml MeOH/H2O 2:1 56 mg lithium hydroxide monohydrate were added and the mixture was stirred over night. The suspension was diluted with 5 ml concentrated HCl to precipitate the acid. After filtration the filter cake was washed twice with water and then dried to yield the acid as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07067665B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-69c7a0c252af43e5b0a9aa16263b32a2 |
| Source note | uspto-grants-2006_06 |