N-(1-pyridin-4-ylethyl)formamide → HCID 22052374, compound

HRID 1831807Notes

Reaction equation

HRID 1831807 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH:9][CH:10]=[O:11])[CH3:8])=[CH:3][CH:2]=1.[H][H]>C(O)(=O)C>[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]([NH:9][CH:10]=[O:11])[CH3:8])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 2771720N-(1-pyridin-4-ylethyl)formamideHCID 178418361HCID 178418361, compound

Product 1

HCID 22052374HCID 22052374, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

N-(1-Pyridin-4-yl-ethyl)-formamide (1.86 g, 12.38 mmol) was dissolved in 50 ml of acetic acid. After addition of Rh (5% on Al2O3, 307 mg) the mixture was hydrogenated with 10 bar hydrogen and 100° C. for 120 hours. The mixture was evaporated and lyophilised. The crude material was used without purification.

Workup

  1. customThe mixture was evaporated
  2. customThe crude material was used without purification

Sources & evidence

ORD record
ord-e9ad8eb38b184374bd02bcba4d2cf473
Source dataset
uspto-grants-2006_06
Patent number
US07067665B2

Reaction notes

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