Hydrochloric Acid → HCID 22052445, compound

HRID 1831818Notes

Reaction equation

HRID 1831818 reaction equation
C([O:3][C:4]([C:6]1[CH:14]=[C:13]([O:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])[C:9]2[O:10][CH2:11][O:12][C:8]=2[CH:7]=1)=[O:5])C.O.[OH-].[Na+].Cl>O1CCOCC1>[Cl:25][C:19]1[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=1[CH2:17][CH2:16][O:15][C:13]1[C:9]2[O:10][CH2:11][O:12][C:8]=2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:14]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 69652272HCID 69652272, compound

Product 1

HCID 22052445HCID 22052445, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

0.41 g (1.07 mmol) of 7-[2-(2,4-Dichloro-phenyl)-ethoxy]-benzo[1,3]dioxole-5-carboxylic acid ethyl ester was dissolved in 15 ml of dioxan. 5 ml of water and 2N aqueous NaOH was added to the solution to give a pH of 13. The reaction solution was heated at 60° C. for 4 h and stirred at room temperature for 16 h. The reaction solution was cooled to 0° C. and concentrated hydrochloric acid was added to give a pH of 1–2, whereupon the product precipitated from solution. The suspension was stirred for 30 min, then the product was filtered off and dried under reduced pressure.

Workup

  1. customto give a pH of 13
  2. temperatureThe reaction solution was cooled to 0° C.
  3. customto give a pH of 1–2
  4. customwhereupon the product precipitated from solution
  5. stirringThe suspension was stirred for 30 min
  6. filtrationthe product was filtered off
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-0f58b40524ed44598aa6fa16ecab1b7b
Source dataset
uspto-grants-2006_06
Patent number
US07067665B2

Reaction notes

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