Acetophenone → HCID 69593803, compound

HRID 1831874Notes

Reaction equation

HRID 1831874 reaction equation
[OH-].[Na+].[CH3:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([I:12])=[CH:8][CH:7]=1)=O.[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[O:19])=[CH:16][CH:15]=1.C(C1C=CC=CC=1)(=O)C>O.C(O)C>[I:12][C:9]1[CH:10]=[CH:11][C:6]([CH:4]=[CH:3][C:18]([C:17]2[CH:20]=[CH:21][C:14]([Br:13])=[CH:15][CH:16]=2)=[O:19])=[CH:7][CH:8]=1

Participants

7

Reactant 4

HCID 7410AcetophenoneHCID 14798Sodium HydroxideHCID 707414-BromobenzaldehydeHCID 728691-(4-Iodophenyl)ethan-1-one

Product 1

HCID 69593803HCID 69593803, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

Sodium hydroxide (5.5 g, 138 mmol) and 4-iodoacetophenone (25.0 g, 102 mmol) were dissolved in water (50 mL) and ethanol (80 mL). 4-Bromo benzaldehyde (18.8 g, 102 mmol) dissolved in ethanol (40 mL) was added dropwise to the acetophenone solution. A slurry quickly formed, which was allowed to stir overnight. The slurry was filtered, was with water until the filtrate was neutral to pH paper, and dried at 100° C. for 12 hours. A light tan solid was obtained (21.1 g, 50% yield).

Workup

  1. customA slurry quickly formed
  2. filtrationThe slurry was filtered
  3. customdried at 100° C. for 12 hours
  4. customA light tan solid was obtained (21.1 g, 50% yield)

Sources & evidence

ORD record
ord-a808bac644f949dc8ebc1f08d02839c3
Source dataset
uspto-grants-2006_06
Patent number
US07067702B2

Reaction notes

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