Bromomethylcyclopropane → HCID 22050628, compound

HRID 1831975Notes

Reaction equation

BrCC1CC1.[Cl:6][C:7]1[C:8](=[O:44])[N:9]([C:23]2[C:41]([F:42])=[CH:40][C:26]([CH2:27][N:28]([CH2:36][CH:37]3[CH2:39][CH2:38]3)C(=O)OC(C)(C)C)=[CH:25][C:24]=2[F:43])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[F:22]>>[ClH:6].[Cl:6][C:7]1[C:8](=[O:44])[N:9]([C:23]2[C:41]([F:42])=[CH:40][C:26]([CH2:27][NH:28][CH2:36][CH:37]3[CH2:38][CH2:39]3)=[CH:25][C:24]=2[F:43])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[F:22]

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 22050849HCID 22050849, compound

Product 1

HCID 22050628HCID 22050628, compound

Procedure

The title compound was prepared by direct analogy with replacing iodomethane with bromocyclopropylmethane and extending the reaction time to 6 hours in Step 1. Step 1: 1 tert-butyl 4-[3-chloro-4-[(2,4-difluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]-3,5-difluorobenzyl(cyclopropylmethyl)carbamate

Workup

customto 6 hours

Sources & evidence

ORD record: ord-400bc2d8b626434ca55ad8a51c4ede1e
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067540B2

Reaction notes

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