Potassium Carbonate → N-(3-{1-[3-(4-Methoxyphenyl)-3-oxopropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1832273Notes

Reaction equation

C([O-])([O-])=O.[K+].[K+].Cl[CH2:8][CH2:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[O:11].[CH3:20][CH:21]([CH3:37])[C:22]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:26]=1)=[O:23]>>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([C:10](=[O:11])[CH2:9][CH2:8][N:34]2[CH2:35][CH2:36][CH:31]([C:27]3[CH:26]=[C:25]([NH:24][C:22](=[O:23])[CH:21]([CH3:20])[CH3:37])[CH:30]=[CH:29][CH:28]=3)[CH2:32][CH2:33]2)=[CH:13][CH:14]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 2332553-Chloro-4'-methoxypropiophenone

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22048734N-(3-{1-[3-(4-Methoxyphenyl)-3-oxopropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Procedure K (KI) and Scheme E (K2CO3) using 3-chloro-1-(4-methoxyphenyl)-1-propanone and 0.2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 409.2 (M+H)+.

Sources & evidence

ORD record: ord-542282c128754b67a6a0a7432b64a107
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Reaction notes

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