Potassium Carbonate → N-(3-{1-[3-(2,3-Dihydro-1H-inden-5-YL)-3-oxopropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1832274Notes

Reaction equation

C([O-])([O-])=O.[K+].[K+].Cl[CH2:8][CH2:9][C:10]([C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[CH2:17][CH2:16][CH2:15]2)=[O:11].[CH3:21][CH:22]([CH3:38])[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:27]=1)=[O:24]>>[CH2:17]1[C:18]2[C:14](=[CH:13][C:12]([C:10](=[O:11])[CH2:9][CH2:8][N:35]3[CH2:36][CH2:37][CH:32]([C:28]4[CH:27]=[C:26]([NH:25][C:23](=[O:24])[CH:22]([CH3:21])[CH3:38])[CH:31]=[CH:30][CH:29]=4)[CH2:33][CH2:34]3)=[CH:20][CH:19]=2)[CH2:15][CH2:16]1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 32867585-(3-Chloropropionyl)indan

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22048796N-(3-{1-[3-(2,3-Dihydro-1H-inden-5-YL)-3-oxopropyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Procedure K (KI) and Scheme E (K2CO3) using 3-chloro-1-(2,3-dihydro-1H-inden-5-yl)-1-propanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 419.2 (M+H)+.

Sources & evidence

ORD record: ord-8e44bd7986c341a1aab2ddeeed711c8b
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Reaction notes

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