4-Chloro-1-butanol → N-(3-[1-(4-hydroxybutyl)-4-piperidinyl]phenyl}-2-methylpropanamide

HRID 1832439Notes

Reaction equation

HRID 1832439 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][OH:6].[CH3:7][CH:8]([CH3:24])[C:9]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:13]=1)=[O:10]>>[OH:6][CH2:5][CH2:4][CH2:3][CH2:2][N:21]1[CH2:22][CH2:23][CH:18]([C:14]2[CH:13]=[C:12]([NH:11][C:9](=[O:10])[CH:8]([CH3:7])[CH3:24])[CH:17]=[CH:16][CH:15]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 135694-Chloro-1-butanolHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22048659N-(3-[1-(4-hydroxybutyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Procedure

Prepared by Procedure G and Scheme B1 using 4-chloro-1-butanol and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 319.3 (M+H)+.

Workup

  1. customPrepared by Procedure G and Scheme B1

Sources & evidence

ORD record
ord-01ffe3f7d6c341ddbc6be437090aa579
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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