4-Fluorophenylacetyl chloride → 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}butyl (4-fluorophenyl)acetate

HRID 1832461Notes

Reaction equation

HRID 1832461 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:7]1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32](Cl)=[O:33])=[CH:27][CH:26]=1>>[F:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]([O:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[CH2:7][CH2:8][CH:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:21])[CH3:22])[CH:13]=3)[CH2:10][CH2:11]2)=[O:33])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 37449884-Fluorophenylacetyl chlorideHCID 22048659N-(3-[1-(4-hydroxybutyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 227253624-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}butyl (4-fluorophenyl)acetate

Procedure

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(4-hydroxybutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and (4-fluorophenyl)acetyl chloride: ESMS m/e: 455.3 (M+H)+.

Workup

  1. customPrepared by Procedure Q1 and Scheme C2 (TEA)

Sources & evidence

ORD record
ord-a2170f593a2e45db89f4d9cb329ef41a
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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