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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832793Generated: October 25, 2026

3-Chloro-4-(propane-2-sulfonyl)-thiophene-2-carbonyl chloride → 3-Chloro-N-(6-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}hexyl)-4-(isopropylsulfonyl)-2-thiophenecarboxamide

https://huagongshe.com/reaction/1832793

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-4-(propane-2-sulfonyl)-thiophene-2-carbonyl chlorideHCID 2778695—
ReactantN-{3-[1-(6-Aminohexyl)4-piperidinyl]phenyl}-2-methylpropanamideHCID 16755868—
SolventTetrahydrofuranHCID 8028—
Product3-Chloro-N-(6-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}hexyl)-4-(isopropylsulfonyl)-2-thiophenecarboxamideHCID 22049587—

Reaction Steps

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(6-aminohexyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-chloro-4-(isopropylsulfonyl)-2-thiophenecarbonyl chloride: ESMS m/e: 596.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-367e2847d11348c8b9807c949ffac115
Source noteuspto-grants-2006_06