Phenyl isocyanate → N-[3-(1-{6-[(Anilinocarbonyl)amino]hexyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 1832794Notes

Reaction equation

HRID 1832794 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1.[C:26]1([N:32]=[C:33]=[O:34])[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C1COCC1>[NH:32]([C:33]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:25])[CH:22]([CH3:23])[CH3:24])[CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 16755868N-{3-[1-(6-Aminohexyl)4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 22049365N-[3-(1-{6-[(Anilinocarbonyl)amino]hexyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(6-aminohexyl)-4-piperidinyl]phenyl}-2-methylpropanamide and phenyl isocyanate: ESMS m/e: 465.2 (M+H)+.

Sources & evidence

ORD record
ord-f93ef3deb6534a2badb95da3742ce344
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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