3,5-Dimethylisoxazole-4-sulfonyl chloride → HCID 22048771, compound

HRID 1832806Notes

Reaction equation

HRID 1832806 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[CH3:23][C:24]1[C:28]([S:29](Cl)(=[O:31])=[O:30])=[C:27]([CH3:33])[O:26][N:25]=1>C1COCC1>[CH3:23][C:24]1[C:28]([S:29]([NH:1][CH2:2][CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:20])[CH3:21])[CH:14]=[CH:15][CH:16]=3)[CH2:7][CH2:6]2)(=[O:31])=[O:30])=[C:27]([CH3:33])[O:26][N:25]=1

Participants

4

Reactant 2

HCID 27363193,5-Dimethylisoxazole-4-sulfonyl chlorideHCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide

Product 1

HCID 22048771HCID 22048771, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3,5-dimethyl-4-isoxazolesulfonyl chloride: ESMS m/e: 463.2 (M+H)+.

Sources & evidence

ORD record
ord-34d4f31e592f44c281e014ec99b76b1f
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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