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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1832814Generated: October 25, 2026

3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride → 3-(2,6-Dichlorophenyl)-N-(5-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}pentyl)-5-methyl-4-isoxazolecarboxamide

https://huagongshe.com/reaction/1832814

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chlorideHCID 78212—
ReactantN-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamideHCID 16755867—
SolventTetrahydrofuranHCID 8028—
Product3-(2,6-Dichlorophenyl)-N-(5-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}pentyl)-5-methyl-4-isoxazolecarboxamideHCID 22048723—

Reaction Steps

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarbonyl chloride. ESMS m/e: 585.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07067534B1
Source datasetuspto-grants-2006_06
ORD IDord-da64425a379d4f248cfcccc5db271546
Source noteuspto-grants-2006_06