Potassium Carbonate → 2-Methyl-N-(3-{1-[5-(4-nitrophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)propanamide

HRID 1832823Notes

Reaction equation

C([O-])([O-])=O.[K+].[K+].Cl[CH2:8][CH2:9][CH2:10][CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=1)=[O:13].[CH3:23][CH:24]([CH3:40])[C:25]([NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:29]=1)=[O:26]>>[CH3:23][CH:24]([CH3:40])[C:25]([NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH:34]2[CH2:39][CH2:38][N:37]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[O:13])[CH2:36][CH2:35]2)[CH:29]=1)=[O:26]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

HCID 220492825-Chloro-1-(4-nitrophenyl)-1-oxopentane

Product 1

HCID 220488632-Methyl-N-(3-{1-[5-(4-nitrophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)propanamide

Procedure

Prepared by Procedure K and Scheme B1 (K2CO3) using 5-chloro-1-(4-nitrophenyl)-1-pentanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 452.2 (M+H)+.

Sources & evidence

ORD record: ord-06731be159954274be4bd92e90dc2a64
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Reaction notes

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