Potassium Carbonate → 2-Methyl-N-[3-(1-(5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl}-4-piperidinyl)phenyl]propanamide

HRID 1832836Notes

Reaction equation

C([O-])([O-])=O.[K+].[K+].[F:7][C:8]([F:23])([F:22])[C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19]Cl)=[CH:11][CH:10]=1.[CH3:24][CH:25]([CH3:41])[C:26]([NH:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[CH:30]=1)=[O:27]>>[CH3:24][CH:25]([CH3:41])[C:26]([NH:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH:35]2[CH2:40][CH2:39][N:38]([CH2:19][CH2:18][CH2:17][CH2:16][C:15](=[O:21])[C:12]3[CH:13]=[CH:14][C:9]([C:8]([F:23])([F:22])[F:7])=[CH:10][CH:11]=3)[CH2:37][CH2:36]2)[CH:30]=1)=[O:27]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 127094795-Chloro-1-oxo-1-(4-trifluoromethylphenyl)pentane

HCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 220492072-Methyl-N-[3-(1-(5-oxo-5-[4-(trifluoromethyl)phenyl]pentyl}-4-piperidinyl)phenyl]propanamide

Procedure

Prepared by Procedure K and Scheme B1 (K2CO3) using 1-[4-(trifluoromethyl)phenyl]-5-chloro-1-pentanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 475.2 (M+H)+.

Sources & evidence

ORD record: ord-cd2739264f2c4a57a941bcc1b1d03c5b
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Reaction notes

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