HCID 1713031, compound → HCID 22049065, compound

HRID 1832970Notes

Reaction equation

HRID 1832970 reaction equation
[CH3:1][C:2]1[C:14]2[N:13]([CH3:15])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[C:4]([CH:16]=O)[CH:3]=1.[CH3:18][CH:19]([CH3:35])[C:20]([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:24]=1)=[O:21]>CC(O)=O>[CH3:1][C:2]1[C:14]2[N:13]([CH3:15])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[C:4]([CH2:16][N:32]2[CH2:33][CH2:34][CH:29]([C:25]3[CH:24]=[C:23]([NH:22][C:20](=[O:21])[CH:19]([CH3:35])[CH3:18])[CH:28]=[CH:27][CH:26]=3)[CH2:30][CH2:31]2)[CH:3]=1

Participants

4

Reactant 2

HCID 1713031HCID 1713031, compoundHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamide

Product 1

HCID 22049065HCID 22049065, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared by Procedure F and Scheme R, without HOAc, using 1,9-dimethyl-9H-carbazole-3-carbaldehyde and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: 1H NMR (400 MHz, CDCl3) δ 8.05–6.77 (m, 10H) 5.20–5.12 (m, 1H), 4.04 (s, 3H) 3.93 (s, 2H), 3.34–3.24 (m, 2H), 2.79 (s, 3H), 2.56–2.38 (m, 2H), 2.38–2.26 (m, 2H), 2.08–1.88 (m, 2H), 1.82–1.70 (m, 2H), 1.16 (d, 6H, J=6.8 Hz); ESMS m/e: 454.2 (M+H)+.

Sources & evidence

ORD record
ord-6a01707264164aaba874fc043b248fe6
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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