Indole → 1-(4-Chlorobutyl)-1H-indole

HRID 1832974Notes

Reaction equation

HRID 1832974 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Br[CH2:11][CH2:12][CH2:13][CH2:14][Cl:15]>>[Cl:15][CH2:14][CH2:13][CH2:12][CH2:11][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 798IndoleHCID 813641-Bromo-4-chlorobutane

Product 1

HCID 123407571-(4-Chlorobutyl)-1H-indole

Procedure

Prepared by Procedure AH, and Scheme P using 1H-indole and 1-bromo-4-chlorobutane: 1NMR (400 MHz, CDCl3) δ 7.72–7.02 (m, 5H), 6.49 (d, 1H, J=2.8 Hz), 4.13 (t, 2H, J=6.8 Hz), 3.48 (t, 2H, J=6.8 Hz), 2.06–1.92 (m, 2H), 1.80–1.70 (m, 2H).

Workup

  1. customPrepared by Procedure AH, and Scheme P

Sources & evidence

ORD record
ord-521a0e1feefb4f179d6d7c6e10646009
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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