反应详情

To a stirred solution of [1-(4-benzyloxy-3-ethoxy-phenyl)-2-phenyl-ethyl]-(2,2-dimethoxy-ethyl)-carbamic acid ethyl ester (12.0 g, 28 mmol) in ethyl acetate (120 mL) and ethanol (60 mL) solution was added 10% Pd/C (2.4 g). The mixture was hydrogenated at 1 atm for 15 hrs. The solution was filtered through a Celite® plug and evaporated to afford a crude oil. Flash chromatography (Merck Silica gel 60, 70–230 mesh, 50% ethyl acetate/hexane) afforded (2,2-dimethoxy-ethyl)-[1-(4-hydroxy-3-methoxy-phenyl)-2-(3-methoxy-phenyl)-ethyl-carbamic acid ethyl ester as a colorless oil. (10 g, 80% yield).

1. filtrationThe solution was filtered through a Celite® plug
2. customevaporated
3. customto afford a crude oil