反应详情

A solution of 6,7-dimethoxy-1-(3-methoxy-5-methyl-benzyl)-3,4-dihydro-isoquinoline-4-carboxylic acid ethyl ester (0.73 g, 1.8 mmol) and 10% palladium on carbon (230 mg) in xylene (15 mL) was refluxed overnight. The reaction mixture was cooled, filtered through celite, and concentrated in vacuo to afford 6,7-dimethoxy-1-(3-methoxy-5-methyl-benzyl)-isoquinoline-4-carboxylic acid ethyl ester as a light brown oil (0.63 g, 89%). This material was used without further purification: 1H NMR (300 MHz) compatible.

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered through celite
3. concentrationconcentrated in vacuo