2-[(4-Amino-3,5-dichloropyridin-2-yl)oxy]ethan-1-ol → HCID 131711011, compound

HRID 1833289Notes

Reaction equation

HRID 1833289 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][N:5]=[C:4]([O:9][CH2:10][CH2:11][OH:12])[C:3]=1[Cl:13]>Cl>[ClH:8].[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][N:5]=[C:4]([O:9][CH2:10][CH2:11][OH:12])[C:3]=1[Cl:13]

Participants

3

Reactant 1

HCID 213886662-[(4-Amino-3,5-dichloropyridin-2-yl)oxy]ethan-1-ol

Product 1

HCID 131711011HCID 131711011, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Ten grams of 4-amino-3,5-dichloro-2-(2-hydroxyethoxy)pyridine, prepared in Example I, was dissolved in 50 milliliters of 5 Normal hydrochloric acid, at ambient temperature, with agitation. The solid which precipitated was recovered by filtration under reduced pressure and dried. The 4-amino-3,5-dichloro-2-(2-hydroxyethoxy)pyridine, hydrochloride product was recovered in a yield of 95 percent of theoretical and melted at 169° C. to 170° C.

Workup

  1. customThe solid which precipitated
  2. filtrationwas recovered by filtration under reduced pressure
  3. customdried
  4. customThe 4-amino-3,5-dichloro-2-(2-hydroxyethoxy)pyridine, hydrochloride product was recovered in a yield of 95 percent of theoretical and melted at 169° C. to 170° C.

Sources & evidence

ORD record
ord-e529f1e01f0d4f1392180991d626480f
Source dataset
uspto-grants-1978_01
Patent number
US04066438

Reaction notes

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