HCID 178476727, compound → HCID 178476726, compound

HRID 1833328Notes

Reaction equation

HRID 1833328 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].C(OC([N:15]1[C:19](=[O:20])[CH2:18][CH2:17][C@H:16]1[C:21]([NH:23][C@H:24]([C:31]([N:33]1[CH2:45][CH2:44][CH2:43][C@H:34]1[C:35]([NH:37][CH2:38][CH2:39][C:40]([NH2:42])=[O:41])=[O:36])=[O:32])[CH2:25][C:26]1[N:30]=[CH:29][NH:28][CH:27]=1)=[O:22])=O)C1C=CC=CC=1.C(OC(N1C(=O)CC[C@H]1C(N[C@H](C(N1CCC[C@H]1C(NCCC(N)=O)=O)=O)CC1N=CNC=1)=O)=O)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[C:1]([OH:4])(=[O:3])[CH3:2].[NH:15]1[C:19](=[O:20])[CH2:18][CH2:17][C@H:16]1[C:21]([NH:23][C@H:24]([C:31]([N:33]1[CH2:45][CH2:44][CH2:43][C@H:34]1[C:35]([NH:37][CH2:38][CH2:39][C:40]([NH2:42])=[O:41])=[O:36])=[O:32])[CH2:25][C:26]1[N:30]=[CH:29][NH:28][CH:27]=1)=[O:22]

Participants

4

Reactant 1

HCID 178476727HCID 178476727, compound

Product 1

HCID 178476726HCID 178476726, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 23938PalladiumSolvent

Procedure

100 mg of benzyloxycarbonyl-L-pyroglutamyl-L-histidyl-L-prolyl-β-alaninamide hemiacetate were dissolved in 20 ml of 0.5-N acetic acid and hydrogenated with the addition of palladium/carbon. The catalyst was filtered off and the filtrate lyophilised. Yield: 80 mg.

Workup

  1. filtrationThe catalyst was filtered off

Sources & evidence

ORD record
ord-b6e69fce34004130b1932bf9fffbe2f3
Source dataset
uspto-grants-1978_01
Patent number
US04066635

Reaction notes

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