8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one → 2,4-dimethyl-8-chloropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one

HRID 1833340Notes

Reaction equation

HRID 1833340 reaction equation
[CH3:1]C1C=C2NC(=O)C3C=NC=CC=3N2N=1.[Cl:16][C:17]1[N:31]=[CH:30][C:20]2[C:21](=[O:29])[NH:22][C:23]3[N:24]([N:25]=[C:26]([CH3:28])[CH:27]=3)[C:19]=2[CH:18]=1>>[CH3:28][C:26]1[CH:27]=[C:23]2[N:22]([CH3:1])[C:21](=[O:29])[C:20]3[CH:30]=[N:31][C:17]([Cl:16])=[CH:18][C:19]=3[N:24]2[N:25]=1

Participants

3

Reactant 2

HCID 1360252228-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-oneHCID 1361423592-Methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one

Product 1

HCID 213891892,4-dimethyl-8-chloropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-oneYield 73%

Procedure

When in Example 3 the 2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one is replaced by the 8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one pf Example 1b, 2,4-dimethyl-8-chloropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one is obtained, yield: 73%; m.p. 253.8° (DMF).

Sources & evidence

ORD record
ord-74d83e5d3a0e4b97abf085f84342e0c3
Source dataset
uspto-grants-1978_01
Patent number
US04066645

Reaction notes

Loading…