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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1833340Generated: October 31, 2026

8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one → 2,4-dimethyl-8-chloropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one

https://huagongshe.com/reaction/1833340

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-oneHCID 136025222—
Reactant2-Methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-oneHCID 136142359—
Product2,4-dimethyl-8-chloropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-oneHCID 2138918973%

Reaction Steps

When in Example 3 the 2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one is replaced by the 8-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one pf Example 1b, 2,4-dimethyl-8-chloropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-5(4H)-one is obtained, yield: 73%; m.p. 253.8° (DMF).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04066645
Source datasetuspto-grants-1978_01
ORD IDord-74d83e5d3a0e4b97abf085f84342e0c3
Source noteuspto-grants-1978_01