反应详情

温度

140 °C

A mixture of 3-aminochromone (8.0 g, 0.05 mole) and diethyl ethoxymethylenemalonate (17.3 g, 0.08 mole) was heated under nitrogen at 140° C. for 2.5 hrs. The reaction mixture was cooled. The product, which crystallized out was filtered off and triturated with petroleum ether. Recrystallization from ethyl acetate - absolute ethanol gave white crystals (10.3 g, 62.5%), m.p. 155°-157° C.

1. temperatureThe reaction mixture was cooled
2. customThe product, which crystallized out
3. filtrationwas filtered off
4. customtriturated with petroleum ether
5. customRecrystallization from ethyl acetate - absolute ethanol