Phenacyl bromide → HCID 20559864, compound

HRID 1833395Notes

Reaction equation

HRID 1833395 reaction equation
[CH2:1]([N:5]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)[CH2:2][CH2:3][CH3:4].[CH2:20]([N:25]([CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C:26]1[CH2:35][CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=1)[CH2:21][CH2:22][CH2:23][CH3:24].[CH2:41]([Br:50])[C:42]([C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)=[O:43]>>[BrH:50].[CH2:41]([C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:14][CH2:15][C:6]=1[N:5]([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:1][CH2:2][CH2:3][CH3:4])[C:42]([C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)=[O:43].[BrH:50].[CH2:6]([C:27]1[C:28]2[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:34][CH2:35][C:26]=1[N:25]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[C:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:43]

Participants

5

Reactant 3

HCID 6259Phenacyl bromideHCID 20559878HCID 20559878, compoundHCID 21389299HCID 21389299, compound

Product 2

HCID 20559864HCID 20559864, compoundHCID 20559872HCID 20559872, compound

Procedure

By following the method of Example 1a the treatment of 2-di-n-butylamino-3,4-dihydro-naphthalene, 2-diamylamino-3,4-dihydronaphthalene, 2-(1-piperidino)-3,4-dihydronaphthalene with phenacylbromide produces 1-phenacyl-2-di-n-butylamino-3,4-dihydronaphthalene hydrobromide, 1-phenacyl-2-diamylamino-3,4-dihydronaphthalene hydrobromide and 1-phenacyl-2-(1-piperidino)-3,4-dihydronaphthalene hydrobromide, respectively.

Sources & evidence

ORD record
ord-afb9d7ea899641aeb27e34ecb587001a
Source dataset
uspto-grants-1978_01
Patent number
US04066659

Reaction notes

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