HCID 85848304, 화합물 → HCID 85848305, 화합물

HRID 1833405노트

반응식

HRID 1833405 반응식
[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[C:4]1=[CH:11][N+:12]([O-])=O)[CH3:2]>[Ni].CO>[CH2:1]([N:3]1[CH2:10][CH:9]2[CH:5]([CH2:6][CH2:7][CH2:8]2)[CH:4]1[CH2:11][NH2:12])[CH3:2]

참가 물질

4

반응물 1

HCID 85848304HCID 85848304, 화합물

생성물 1

HCID 85848305HCID 85848305, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

54 parts of N-ethyl-2-nitromethylene-3-azabicyclo (3,3,0) octane, in solution in 500 parts of anhydrous methanol were reduced in presence of 20 parts of Raney Nickel at 5 kg/m2 pressure. After filtration and washing of the catalyst by methanol, the filtrate was evaporated under vacuo then distilled. There were obtained 30 parts of N-ethyl-2-aminomethyl-3-azabicyclo (3,3,0) octane, B.P./0.25-0.30 mm Hg : 88°-90° C. This reduction can be easily carried out with lithium aluminium hydride too.

후처리

  1. filtrationAfter filtration
  2. washwashing of the catalyst by methanol
  3. customthe filtrate was evaporated under vacuo
  4. distillationthen distilled

출처 및 근거

ORD 기록
ord-ede917f965b34ece8d8a70af42dc2f3e
출처 데이터셋
uspto-grants-1978_01
특허 번호
US04066662

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