3-Amino-1-propanol → HCID 21389382, compound

HRID 1833425Notes

Reaction equation

HRID 1833425 reaction equation
[C:1]([OH:26])(=[O:25])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]#[C:11][C:12]#[C:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=O.[OH:27][CH2:28][CH2:29][CH2:30][NH2:31]>CCOCC>[OH:27][CH2:28][CH2:29][CH2:30][NH:31][C:22]([CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][C:13]#[C:12][C:11]#[C:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([O-:26])=[O:25])=[O:24].[OH:27][CH2:28][CH2:29][CH2:30][NH3+:31]

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 54413810,12-Docosadiynedioic acid

Product 1

HCID 21389382HCID 21389382, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 9.4 g. (0.025 mole, 376.59) of monomethyl ester of 10,12-docosadiynedioic acid and 11.3 g. (0.12 mole, 75.11) of 3-hydroxypropylamine is briefly warmed, then kept overnight at room temperature. The product is slurried with ether, then recrystallized from an ether-ethanol mixture, obtaining a white solid, m.p. 91°-3° C.

Workup

  1. additionA mixture of 9.4 g
  2. customrecrystallized from an ether-ethanol mixture
  3. customobtaining a white solid, m.p. 91°-3° C.

Sources & evidence

ORD record
ord-34f8434f30cc4907b1a13412cc763cd2
Source dataset
uspto-grants-1978_01
Patent number
US04066676

Reaction notes

Loading…