Acetic Acid → 4-(8-(3,4-Difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-(6-methylpyrimidin-4-yl)piperidine-4-carbonitrile

HRID 183359Notes

Reaction equation

HRID 183359 reaction equation
[C:39]([OH:40])(=[O:41])[CH3:42].[CH3:1][c:2]1[cH:3][c:4]([N:8]2[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]2)[n:5][cH:6][n:7]1.[CH3:33][Si:34]([CH3:35])([CH3:36])[C:37]#[N:38].[F:15][c:16]1[cH:17][c:18](-[c:23]2[c:24]3[n:25]([cH:26][cH:27][cH:28]2)[n:29][c:30]([NH2:32])[n:31]3)[cH:19][cH:20][c:21]1[F:22]>>[CH3:1][c:2]1[cH:3][c:4]([N:8]2[CH2:9][CH2:10][C:11]([NH:32][c:30]3[n:29][n:25]4[c:24]([c:23](-[c:18]5[cH:17][c:16]([F:15])[c:21]([F:22])[cH:20][cH:19]5)[cH:28][cH:27][cH:26]4)[n:31]3)([C:37]#[N:38])[CH2:12][CH2:13]2)[n:5][cH:6][n:7]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 82115Trimethylsilyl cyanideHCID 61226887HCID 61226887, compoundHCID 673372048-(3,4-Difluorophenyl)-[1,2,4]triazolo[1,5-A]pyridin-2-amine

Product 1

HCID 583979704-(8-(3,4-Difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-(6-methylpyrimidin-4-yl)piperidine-4-carbonitrile

Sources & evidence

ORD record
ord-4f685a3e63a84054a8f607da330fc685
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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