Ethylene Oxide → HCID 86735362, compound

HRID 1833715Notes

Reaction equation

HRID 1833715 reaction equation
CC1C=CC(C(C=C(N[CH2:12][CH:13]([OH:29])[CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([O:22]CCOCCC)=[CH:18][CH:17]=2)C)=O)=CN=1.[C:32]1([CH:39]=CC(O)=[CH:35][CH:34]=1)O.[CH2:40]([O:47][CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[CH:51]C=1)[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1.C1OC1>>[CH2:13]([OH:29])[CH2:14][OH:15].[CH2:14]([O:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][C:53]2[CH:54]=[CH:49][C:48]([O:47][CH2:40][C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)=[CH:51][CH:52]=2)=[CH:20][CH:21]=1)[C:13]1[CH:12]=[CH:35][CH:34]=[CH:32][CH:39]=1

Participants

4

Reactant 3

HCID 6354Ethylene OxideHCID 20056808HCID 20056808, compoundHCID 70618959HCID 70618959, compound

Product 1

HCID 86735362HCID 86735362, compound

Procedure

The 1-(2-[6-methyl-nicotinoyl]-1-methyl-vinylamino)-3-(p-[2-n-propoxy-ethoxy]-phenoxy)-propan-2-ol of the formula ##STR146## required as reactant can be prepared as follows: a. 450.0 g. of hydroquinone-monobenzylether and 20.0 g. of potassium tertiary butylate are heated to 105° C. in an autoclave holding 700 ml. 19.4 g. of ethylene oxide each are pressed, while stirring, into the autoclave five times at half-hour's intervals. After a further one-hour stirring at 105° C. the reaction is complete. By recrystallizing the reaction product from isopropanol, 477.5 g. of ethyleneglycol-mono-(4-benzyloxy-phenyl)-ether of the formula ##STR147## are obtained.

Workup

  1. customcan be prepared
  2. stirringAfter a further one-hour stirring at 105° C. the reaction
  3. customBy recrystallizing the reaction product from isopropanol, 477.5 g

Sources & evidence

ORD record
ord-605576e4a94c4f399454264deb43f019
Source dataset
uspto-grants-1978_01
Patent number
US04066768

Reaction notes

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