Ethylene Oxide → HCID 86735362, compound

Participants

Reaction Steps

The 1-(2-[6-methyl-nicotinoyl]-1-methyl-vinylamino)-3-(p-[2-n-propoxy-ethoxy]-phenoxy)-propan-2-ol of the formula ##STR146## required as reactant can be prepared as follows: a. 450.0 g. of hydroquinone-monobenzylether and 20.0 g. of potassium tertiary butylate are heated to 105° C. in an autoclave holding 700 ml. 19.4 g. of ethylene oxide each are pressed, while stirring, into the autoclave five times at half-hour's intervals. After a further one-hour stirring at 105° C. the reaction is complete. By recrystallizing the reaction product from isopropanol, 477.5 g. of ethyleneglycol-mono-(4-benzyloxy-phenyl)-ether of the formula ##STR147## are obtained.

Provenance & Evidence