Chloroform → HCID 21387510, compound

Participants

Reaction Conditions

Reaction Steps

50 ml of methyl isocyanate were added to a solution of 15 g of 3-hydroxy-5-benzyl-1,2,4-thiadiazole in 400 ml of isopropyl ether and the mixture was stirred at 20° C for 72 hours. 50 ml of chloroform were added thereto and the mixture was vacuum filtered. The recovered crystals were dried to obtain 10 g of 2-(methylcarbamoyl)-5-benzyl-1,2,4-thiadiazole-3-one melting at 146° C.

Provenance & Evidence