Chloroform → HCID 21387510, compound

HRID 1833799Notes

Reaction equation

HRID 1833799 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[OH:5][C:6]1[N:10]=[C:9]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:8][N:7]=1.C(Cl)(Cl)Cl>C(OC(C)C)(C)C>[CH3:1][NH:2][C:3]([N:7]1[C:6](=[O:5])[N:10]=[C:9]([CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[S:8]1)=[O:4]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 12228Methyl IsocyanateHCID 178519013HCID 178519013, compound

Product 1

HCID 21387510HCID 21387510, compound

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Conditions

Temperature
20 °C

Procedure

50 ml of methyl isocyanate were added to a solution of 15 g of 3-hydroxy-5-benzyl-1,2,4-thiadiazole in 400 ml of isopropyl ether and the mixture was stirred at 20° C for 72 hours. 50 ml of chloroform were added thereto and the mixture was vacuum filtered. The recovered crystals were dried to obtain 10 g of 2-(methylcarbamoyl)-5-benzyl-1,2,4-thiadiazole-3-one melting at 146° C.

Workup

  1. filtrationfiltered
  2. customThe recovered crystals were dried

Sources & evidence

ORD record
ord-8182b7d323564a23bf5cbf399a71ea1a
Source dataset
uspto-grants-1978_01
Patent number
US04067720

Reaction notes

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