2-Chloroethyl isocyanate → HCID 54327014, compound

HRID 1833802Notes

Reaction equation

HRID 1833802 reaction equation
[Cl:1][CH2:2][CH2:3][N:4]=[C:5]=[O:6].[OH:7][C:8]1[N:12]=[C:11]([O:13][CH2:14][CH3:15])[S:10][N:9]=1>C1C=CC=CC=1>[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:9]1[C:8](=[O:7])[N:12]=[C:11]([O:13][CH2:14][CH3:15])[S:10]1)=[O:6]

Participants

4

Reactant 2

HCID 160352-Chloroethyl isocyanateHCID 178467476HCID 178467476, compound

Product 1

HCID 54327014HCID 54327014, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
20 °C

Procedure

41 g of β-chloroethyl isocyanate were added to a solution of 28.7 g of 3-hydroxy-5-ethoxy-1,2,4-thiadiazole in 500 ml of benzene and after stirring for 17 hours at 20° C, the mixture was filtered. The filtrate was evaporated to dryness and the residue was empasted with isopropyl ether and was dried to obtain 47 g of 2-(N-β-chloroethylcarbamoyl)-5-ethoxy-1,2,4-thiadiazole-3-one melting at 82° C.

Workup

  1. filtrationthe mixture was filtered
  2. customThe filtrate was evaporated to dryness
  3. customwas dried

Sources & evidence

ORD record
ord-7320532fe43d40bf94e2b8d924f46bd9
Source dataset
uspto-grants-1978_01
Patent number
US04067720

Reaction notes

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