Methyl Isocyanate → HCID 12526282, compound

HRID 1833811Notes

Reaction equation

HRID 1833811 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[OH:5][C:6]1[N:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[S:8][N:7]=1>O1CCCC1>[CH3:1][NH:2][C:3]([N:7]1[C:6](=[O:5])[N:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[S:8]1)=[O:4]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 178519016HCID 178519016, compound

Product 1

HCID 12526282HCID 12526282, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

5 ml of methyl isocyanate were added to a solution of 12.1 g of 3-hydroxy-5-(p-chlorobenzyloxy)-1,2,4-thiadiazole in 150 ml tetrahydrofuran and the mixture was stirred for 2 hours and 20° C and then concentrated to dryness. The residue was crystallized from ethyl acetate to obtain 7.3g of 2-(N-methylcarbamoyl)-5-(p-chlorobenzyloxy)-1,2,4-thiadiazole-3-one melting at 145° C.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-7897ab07fd524bd4ba25f0b136fe9a69
Source dataset
uspto-grants-1978_01
Patent number
US04067720

Reaction notes

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