Formic Acid → HCID 21387635, compound

(±) 1-(2-Furyl)-1-phenylethanol (43 g.) was dissolved in a solution of hydrazine hydrate (25 ml.) in ethanol (100 ml.). Formic acid (23 ml.) was added to the solution cautiously in portions and the heterogeneous mixture was heated at reflux on a steam bath for 4 hours. After 1 hour the mixture became homogeneous. The solution was evaporated to low volume and the residue was digested with a mixture of diethyl ether (100 ml.) and water (200 ml.). Dilute sodium hydroxide solution was added to adjust the pH to 9 and the ether layer was separated. The aqueous layer was extracted with diethyl ether (2 × 150 ml.) and the combined ethereal extracts were washed with water (3 × 150 ml.) and filtered. The filtrate was extracted with 2N hydrochloric acid (5 × 100 ml.). The combined acidic extracts were washed with diethyl ether (2 × 200 ml.) and basified by the addition of 50% aqueous sodium hydroxide solution. The oil which was deposited was extracted with diethyl ether (2 × 200 ml.) and the combined extracts were washed with water (2 × 200 ml.), dried over sodium sulphate, filtered and evaporated to give a brown oil, which was distilled to give 3-(1-phenylethyl)pyridazine (5.4 g.), m.p. 43°-48° C. (b.p. 120° C./0.05 mm.Hg), as an off-white solid.

1. temperaturethe heterogeneous mixture was heated
2. temperatureat reflux on a steam bath for 4 hours
3. customThe solution was evaporated to low volume
4. additionthe residue was digested with a mixture of diethyl ether (100 ml.) and water (200 ml.)
5. additionDilute sodium hydroxide solution was added
6. customthe ether layer was separated
7. extractionThe aqueous layer was extracted with diethyl ether (2 × 150 ml.)
8. washthe combined ethereal extracts were washed with water (3 × 150 ml.)
9. filtrationfiltered
10. extractionThe filtrate was extracted with 2N hydrochloric acid (5 × 100 ml.)
11. washThe combined acidic extracts were washed with diethyl ether (2 × 200 ml.)
12. additionbasified by the addition of 50% aqueous sodium hydroxide solution
13. extractionThe oil which was deposited was extracted with diethyl ether (2 × 200 ml.)
14. washthe combined extracts were washed with water (2 × 200 ml.)
15. dry with materialdried over sodium sulphate
16. filtrationfiltered
17. customevaporated
18. customto give a brown oil, which
19. distillationwas distilled

ORD record

ord-b4edb106ac444f6c857c46c9ad75f7c6

Source dataset

uspto-grants-1978_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04067723