Cyclohexane → HCID 21387635, compound

HRID 1833863Notes

Reaction equation

HRID 1833863 reaction equation
[C:1]([C:3]([C:11]1[N:12]=[N:13][CH:14]=[CH:15][CH:16]=1)([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)C)#N.[OH-].[K+].C1CCCCC1>C(O)CO.O>[C:5]1([CH:3]([C:11]2[N:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH3:1])[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

6

Reactant 3

HCID 8078CyclohexaneHCID 14797Potassium HydroxideHCID 21387531HCID 21387531, compound

Product 1

HCID 21387635HCID 21387635, compoundYield 56.8%

Reagents, catalysts & solvents 2

HCID 174Ethylene GlycolSolventHCID 962WaterSolvent2×

Procedure

A solution of 3-(1-cyano-1-phenylethyl)-pyridazine (1 g.) in ethylene glycol (10 ml.) and water (1 ml.) containing potassium hydroxide (0.3 g.) was heated at reflux for 6 hours. The yellow solution was diluted with water (40 ml.) and extracted with chloroform (3 × 25 ml.), dried over magnesium sulphate, filtered and evaporated to give a cream-coloured solid (0.8 g.). 3-(1-Phenylethyl)pyridazine (0.5 g.), m.p. 44°-45° C., was obtained from the cream-coloured solid in the form of colourless crystals by recrystallisation from cyclohexane.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 6 hours
  3. extractionextracted with chloroform (3 × 25 ml.)
  4. dry with materialdried over magnesium sulphate
  5. filtrationfiltered
  6. customevaporated
  7. customto give a cream-coloured solid (0.8 g.)

Sources & evidence

ORD record
ord-b1a3b6f3072248bdb38621a757b95109
Source dataset
uspto-grants-1978_01
Patent number
US04067723

Reaction notes

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