Cyclohexane → HCID 21387635, compound

Participants

Reaction Steps

A solution of 3-(1-cyano-1-phenylethyl)-pyridazine (1 g.) in ethylene glycol (10 ml.) and water (1 ml.) containing potassium hydroxide (0.3 g.) was heated at reflux for 6 hours. The yellow solution was diluted with water (40 ml.) and extracted with chloroform (3 × 25 ml.), dried over magnesium sulphate, filtered and evaporated to give a cream-coloured solid (0.8 g.). 3-(1-Phenylethyl)pyridazine (0.5 g.), m.p. 44°-45° C., was obtained from the cream-coloured solid in the form of colourless crystals by recrystallisation from cyclohexane.

Provenance & Evidence