HCID 21387991, compound → STK374259

HRID 1833881Notes

Reaction equation

HRID 1833881 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[NH:13][C:14](=[O:21])[NH:15]C(OCC)=O)=O>CN(C)C=O>[F:1][C:2]1[CH:25]=[CH:24][CH:23]=[CH:22][C:3]=1[C:4]1[C:6]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:12])[CH:11]=2)[NH:13][C:14](=[O:21])[N:15]=1

Participants

3

Reactant 1

HCID 21387991HCID 21387991, compound

Product 1

HCID 4564737STK374259

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Ethyl 4-(2-(o-fluorobenzoyl)-4-chlorophenyl)-allophanate (50 mg) was dissolved in dimethylformamide and the mixture was heated to the reflux temperature to deposit crystals. The crystals were collected by filtration and dried to give 4-(o-fluorophenyl)-6-chloro-2(1H)-quinazolinone having a melting point of over 300° C.

Workup

  1. temperaturethe mixture was heated to the reflux temperature to deposit crystals
  2. filtrationThe crystals were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-30e36a8008894a179b019453a4d49362
Source dataset
uspto-grants-1978_01
Patent number
US04067868

Reaction notes

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