Thionyl Chloride → HCID 21388394, compound

HRID 1834036Notes

Reaction equation

HRID 1834036 reaction equation
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([O:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[C:19]([C:24]([F:27])([F:26])[F:25])[CH:18]=2)[C:13](O)=[O:14])=[CH:8][CH:7]=1>C(Cl)(Cl)Cl>[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([O:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[C:19]([C:24]([F:27])([F:26])[F:25])[CH:18]=2)[C:13]([Cl:3])=[O:14])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21388393HCID 21388393, compound

Product 1

HCID 21388394HCID 21388394, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

11.45 g (0.096 mol) of freshly distilled thionyl chloride are added to a suspension of 28.65 g (0.077 mol) of 2-(4-chloro-phenyl)-2-(4-fluoro-3-trifluoromethylphenoxy)-acetic acid in 35 ml of dry chloroform. The mixture is stirred for 30 minutes at ambient temperature and is then heated at the reflux temperature until all the acid has dissolved (about 6 hours). The solution is evaporated to dryness under reduced pressure and 2-(4-chlorophenyl)-2-(4-fluoro-3-trifluoromethyl-phenoxy)-acetyl chloride is obtained in the form of an oil, which is used without further purification for the next stage of the synthesis.

Workup

  1. temperatureis then heated at the reflux temperature until all the acid
  2. dissolutionhas dissolved (about 6 hours)
  3. customThe solution is evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-af4a0d2a9d6d4803a8bc98250bf22dea
Source dataset
uspto-grants-1978_01
Patent number
US04067996

Reaction notes

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