Thionyl Chloride → HCID 21388394, compound

Participants

Reaction Steps

11.45 g (0.096 mol) of freshly distilled thionyl chloride are added to a suspension of 28.65 g (0.077 mol) of 2-(4-chloro-phenyl)-2-(4-fluoro-3-trifluoromethylphenoxy)-acetic acid in 35 ml of dry chloroform. The mixture is stirred for 30 minutes at ambient temperature and is then heated at the reflux temperature until all the acid has dissolved (about 6 hours). The solution is evaporated to dryness under reduced pressure and 2-(4-chlorophenyl)-2-(4-fluoro-3-trifluoromethyl-phenoxy)-acetyl chloride is obtained in the form of an oil, which is used without further purification for the next stage of the synthesis.

Provenance & Evidence