Dichloromethane → HCID 22765685, compound

HRID 1834107Notes

Reaction equation

HRID 1834107 reaction equation
Cl.[CH2:2]([NH:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH:3]=[CH2:4].C(Cl)Cl.[Cl:13][CH:14]([Cl:18])[C:15](Cl)=[O:16]>C(N(CC)CC)C>[CH2:2]([N:5]([CH2:6][CH2:7][CH2:8][CH3:9])[C:15](=[O:16])[CH:14]([Cl:18])[Cl:13])[CH:3]=[CH2:4]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6593Dichloroacetyl chlorideHCID 20193689N-(Prop-2-en-1-yl)butan-1-amine--hydrogen chloride (1/1)

Product 1

HCID 22765685HCID 22765685, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Ten and five-tenths grams of allyl-n-butyl amine hydrochloride was added to 100 ml. of methylene chloride followed by 14.5 g. of triethylamine. The mixture was stirred in a water bath at room temperature while 10.4 g. of dichloroacetyl chloride was added dropwise, and stirring was continued for 30 minutes after addition was complete. The mixture was washed and the solvent stripped under vacuum. Yield was 13 g., nD30 1.4603. The intermediate was used without further purification to prepare Compound No. 12 (Example VII).

Workup

  1. stirringstirring
  2. additionafter addition
  3. washThe mixture was washed
  4. customThe intermediate was used without further purification
  5. customto prepare Compound No

Sources & evidence

ORD record
ord-c4f6d65782d343dfbad6f8dc53dc3ced
Source dataset
uspto-grants-1978_01
Patent number
US04069038

Reaction notes

Loading…