Sodium Hydroxide → HCID 22749369, compound

HRID 1834174Notes

Reaction equation

HRID 1834174 reaction equation
[CH3:1][N:2]([C:18]([CH2:23][OH:24])([CH2:21][OH:22])[CH2:19][OH:20])[C:3](=[O:17])[C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([N+:14]([O-:16])=[O:15])[CH:13]=1)[C:7]([O:9]C)=[O:8].[OH-].[Na+]>CO>[CH3:1][N:2]([C:18]([CH2:23][OH:24])([CH2:19][OH:20])[CH2:21][OH:22])[C:3](=[O:17])[C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([N+:14]([O-:16])=[O:15])[CH:13]=1)[C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22749370Methyl N-methyl-5-nitro-N-[tris(hydroxymethyl)methyl]isophthalamate

Product 1

HCID 22749369HCID 22749369, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl N-methyl-5-nitro-N-[tris(hydroxymethyl)methyl]isophthalamate is stirred with one equivalent of sodium hydroxide in aqueous methanol. The reaction mixture is concentrated to remove the methanol, diluted with water and acidified with mineral acid to provide crystalline N-methyl-5-nitro-N-[tris (hydroxymethyl)methyl]isophthalamic acid.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customto remove the methanol
  3. additiondiluted with water

Sources & evidence

ORD record
ord-03a4d7f21d94406da5dbe5005ae1f081
Source dataset
uspto-grants-1978_01
Patent number
US04069250

Reaction notes

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