O,O-diethyl phosphorochloridothioate → HCID 12526293, compound

HRID 1834187Notes

Reaction equation

HRID 1834187 reaction equation
[P:1](Cl)([O:6][CH2:7][CH3:8])([O:3][CH2:4][CH3:5])=[S:2].[OH:10][C:11]1[N:15]=[C:14]([N:16]([CH3:18])[CH3:17])[S:13][N:12]=1>>[CH2:4]([O:3][P:1]([O:10][C:11]1[N:15]=[C:14]([N:16]([CH3:18])[CH3:17])[S:13][N:12]=1)([O:6][CH2:7][CH3:8])=[S:2])[CH3:5]

Participants

3

Reactant 2

HCID 17305O,O-diethyl phosphorochloridothioateHCID 178483103HCID 178483103, compound

Product 1

HCID 12526293HCID 12526293, compound

Procedure

Using the procedure of Example 6, diethyl chlorothiophosphate and 3 -hydroxy-5-dimethylamino-1,2,4-thiadiazole were reacted and after chromatography and elution with an 8-2benzene-ethylacetate mixture, there was obtained 3-(diethoxythiophosphoryloxy)-5-dimethylamino-1,2,4-thiadiazole with a melting point of 48° C and Rf=0.55.

Workup

  1. customwere reacted
  2. washafter chromatography and elution with an 8-2benzene-ethylacetate mixture

Sources & evidence

ORD record
ord-41a133b378194175818d37621db2e513
Source dataset
uspto-grants-1978_01
Patent number
US04069319

Reaction notes

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