6-Aminopyridazine-3-carboxylic acid → (6-Aminopyridazin-3-yl)methanol

HRID 1834258Notes

Reaction equation

HRID 1834258 reaction equation
[NH2:1][C:2]1[N:7]=[N:6][C:5]([C:8](O)=[O:9])=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][C:2]1[N:7]=[N:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 122004796-Aminopyridazine-3-carboxylic acidHCID 21226445Aluminium lithium hydride

Product 1

HCID 20557894(6-Aminopyridazin-3-yl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-Amino-3-pyridazinecarboxylic acid is converted to the methyl ester and the ester is reduced with lithium aluminium hydride in tetrahydrofuran to give 6-amino-3-hydroxymethylpyridazine.

Sources & evidence

ORD record
ord-aabc44701c2548beab210827ab8cafee
Source dataset
uspto-grants-1978_01
Patent number
US04069327

Reaction notes

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