Dimethylformamide → HCID 20338976, compound

HRID 1834353Notes

Reaction equation

HRID 1834353 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[CH:5]([O:8][C:9]1[CH:14]=[C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:17]=2[Cl:26])[CH:12]=[CH:11][C:10]=1Br)[CH2:6][CH3:7])[CH3:2].[CH3:29][N:30](C)C=O>>[CH2:1]([O:3][C:4](=[O:28])[CH:5]([O:8][C:9]1[CH:14]=[C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][C:17]=2[Cl:26])[CH:12]=[CH:11][C:10]=1[C:29]#[N:30])[CH2:6][CH3:7])[CH3:2]

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 20338977HCID 20338977, compound

Product 1

HCID 20338976HCID 20338976, compound

Procedure

A 10 g of ethyl-α-[2-bromo-5-(2-chloro-4-trifluoromethyl phenoxy) phenoxy]butyrate was dissolved in 20 ml of dimethylformamide. A 2.5 g of cuprous cyanide was added to the solution and the reaction was conducted at 145° to 150° C for 4 hours with stirring the mixture. The reaction mixture was poured into suitable amount of an aqueous solution of ferric chloride. The product was extracted with chloroform. The extract was washed with water and was dried. The chloroform was evaporated off and the product was distilled at reduced pressure to obtain 6 g of the object compound having a boiling point of 200° to 205° C/1 mmHg.

Workup

  1. extractionThe product was extracted with chloroform
  2. washThe extract was washed with water
  3. customwas dried
  4. customThe chloroform was evaporated off
  5. distillationthe product was distilled at reduced pressure

Sources & evidence

ORD record
ord-bfa9d6be1c3743bcbc047de4abacdc0f
Source dataset
uspto-grants-1978_01
Patent number
US04070177

Reaction notes

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