Dimethylformamide → HCID 20339019, compound

HRID 1834354Notes

Reaction equation

HRID 1834354 reaction equation
Br[C:2]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[Cl:25])=[CH:10][C:3]=1[O:4][CH:5]([CH2:8][CH3:9])[C:6]#[N:7].[CH3:26][N:27](C)C=O>>[C:26]([C:2]1[CH:13]=[CH:12][C:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[Cl:25])=[CH:10][C:3]=1[O:4][CH:5]([CH2:8][CH3:9])[C:6]#[N:7])#[N:27]

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 20339020HCID 20339020, compound

Product 1

HCID 20339019HCID 20339019, compound

Procedure

A 10 g of α-[2-bromo-5-(2-chloro-4-trifluoromethyl phenoxy) phenoxy]butyronitrile was dissolved in 20 ml of dimethylformamide. A 2.5 g of cuprous cyanide was added to the solution and the reaction was conducted at 145° to 150° C for 2 hours with stirring the mixture. The reaction mixture was cooled and was poured into suitable amount of aqueous solution of ferric chloride. The product was extracted with chloroform and the extract was washed with water and was dried. The chloroform was distilled off and the product was distilled at reduced pressure to obtain 7 g of the object compound having the boiling point of 202° to 207° C/2 mmHg.

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionThe product was extracted with chloroform
  3. washthe extract was washed with water
  4. customwas dried
  5. distillationThe chloroform was distilled off
  6. distillationthe product was distilled at reduced pressure

Sources & evidence

ORD record
ord-b5091f1da7484bdea48c104ebeb6e79d
Source dataset
uspto-grants-1978_01
Patent number
US04070177

Reaction notes

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