HCID 20373034, compound → HCID 20373040, compound

HRID 1834380Notes

Reaction equation

HRID 1834380 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]1[C:33](=[O:34])[N:15]2[C:16]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:17]=3[N:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](=[O:21])[CH:20]=[C:14]2[NH:13]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:33](=[O:34])[N:15]2[C:16]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][C:17]=3[N:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19](=[O:21])[CH:20]=[C:14]2[NH:13]1

Participants

3

Reactant 1

HCID 20373034HCID 20373034, compound

Product 1

HCID 20373040HCID 20373040, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2.5 g of 2-[3-(t-butoxycarbonylamino)propyl]-8-chloro-6-phenyl-1H-s-triazolo[4,3-a][1,5]benzodiazepine-1,5-dione in 50 ml of trifluoroacetic acid is stirred at room temperature for 2 hours. The reaction is evaporated and the residue is stirred with a solution of 1.9 g of sodium bicarbonate in 400 ml of methanol-water (10:1). After 3 hours the reaction is evaporated and the residue is partitioned between methylene chloride and water. The methylene chloride is washed with water, dried and evaporated to give the title compound.

Workup

  1. customThe reaction is evaporated
  2. customAfter 3 hours the reaction is evaporated
  3. customthe residue is partitioned between methylene chloride and water
  4. washThe methylene chloride is washed with water
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-d316aabc4ecb475b80d3b020d55d562e
Source dataset
uspto-grants-1978_01
Patent number
US04070355

Reaction notes

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