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HRID1834401

反应详情

EQUATION

反应方程式

HRID 1834401 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)C(C)c1cc(C)c(C(=O)c2ccc(Cl)cc2)n1C
HCID118464

Ethyl 2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]propanoate

C18H20ClNO3

PRODUCTS

生成物

1
结构：Cc1cc(C(C)C(=O)O)n(C)c1C(=O)c1ccc(Cl)cc1
HCID198126

2-[5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]propanoic acid

C16H16ClNO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

An ethanol solution of 2.9 g. (0.0087 mole) of ethyl 5-(p-chlorobenzoyl)-1,4,α-trimethylpyrrole-2-acetate is added to 17.5 ml. 0.5 N sodium hydroxide solution and the mixture is heated under reflux for 1 hour. The ethanol is evaporated in vacuo and the solution poured into dilute hydrochloric acid. The precipitated solid is collected by filtration and recrystallized from ether-cyclohexane to give 5-(p-chlorobenzoyl)-1,4,α-trimethylpyrrole-2-acetic acid as a white solid, m.p. 153°-154° C.

WORKUP

后处理

  1. temperatureunder reflux for 1 hour
  2. customThe ethanol is evaporated in vacuo
  3. additionthe solution poured into dilute hydrochloric acid
  4. filtrationThe precipitated solid is collected by filtration
  5. customrecrystallized from ether-cyclohexane