HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Mcn 2891
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ethyl 5-(4-chlorobenzoyl)-alpha,1,4-trimethyl-1H-pyrrole-2-acetate | HCID 118464 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Mcn 2891 | HCID 198126 | — |
Reaction Steps
An ethanol solution of 2.9 g. (0.0087 mole) of ethyl 5-(p-chlorobenzoyl)-1,4,α-trimethylpyrrole-2-acetate is added to 17.5 ml. 0.5 N sodium hydroxide solution and the mixture is heated under reflux for 1 hour. The ethanol is evaporated in vacuo and the solution poured into dilute hydrochloric acid. The precipitated solid is collected by filtration and recrystallized from ether-cyclohexane to give 5-(p-chlorobenzoyl)-1,4,α-trimethylpyrrole-2-acetic acid as a white solid, m.p. 153°-154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04070368 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-e2f012da2aa74fbd8e50a955245cad74 |
| Source note | uspto-grants-1978_01 |