Acetophenone → HCID 20373143, compound

HRID 1834414Notes

Reaction equation

HRID 1834414 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].C(OC(=O)C)(=O)C.I.[PH2](O)=O.[CH3:21][C:22]1[NH:23][CH:24]=[C:25]([CH3:30])[C:26]=1[C:27](=[O:29])[CH3:28]>O>[CH3:21][C:22]1[NH:23][C:24]([CH:1]([CH3:2])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[C:25]([CH3:30])[C:26]=1[C:27](=[O:29])[CH3:28]

Participants

7

Reactant 5

HCID 7410AcetophenoneHCID 7918Acetic Anhydride2×HCID 15163Ketone, 2,4-dimethylpyrrol-3-yl methylHCID 24841Hydrogen iodideHCID 4124402Phosphinic Acid

Product 1

HCID 20373143HCID 20373143, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.6 ml of acetophenone of 5 ml of acetic anhydride was slowly added to a stirred mixture of 10 ml of aqueous hydriodic acid, 10 ml of acetic anhydride and 2 ml of hypophosphorous acid containing 548 mg of 2,4-dimethyl-3-acetyl pyrrole. The mixture was allowed to stand for two days at room temperature then poured into water. The crude product which separated was recrystallized from acetone (thimble) as nearly colourless rhombic plates (75%), mp. 146°-148.5° C. Anal. Calc. For C16H19NO: C, 79.63; H, 7.94; N, 5.80. Found: C, 79.47: H, 7.78; N, 5.79.

Workup

  1. customThe crude product which separated
  2. customwas recrystallized from acetone (thimble) as nearly colourless rhombic plates (75%), mp. 146°-148.5° C

Sources & evidence

ORD record
ord-6947713c433645f7918b2b312d6e865a
Source dataset
uspto-grants-1978_01
Patent number
US04070366

Reaction notes

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